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GPAT Clinical Pharmacy and Therapeutics Flashcards
51 question-and-answer cards covering Clinical Pharmacy and Therapeutics as it is examined in GPAT. 24 of them are printed below, taken from across the deck — no signup, no paywall on the preview.
24 sample cards from the Clinical Pharmacy and Therapeutics deck
Sampled from the end of the deck, so these are different cards from the ones shown on the syllabus page.
Which anti-TB drug causes optic neuritis and color blindness?
Ethambutol.
What is the most common adverse effect of isoniazid and how is it prevented?
Peripheral neuropathy, prevented by co-administration of pyridoxine (vitamin B6).
What does HAART stand for in HIV management?
Highly Active Antiretroviral Therapy - a combination regimen typically of two NRTIs plus an NNRTI, integrase inhibitor, or protease inhibitor.
Which drug is the first-line treatment for uncomplicated Plasmodium falciparum malaria (WHO)?
Artemisinin-based combination therapy (ACT), e.g., artemether-lumefantrine.
Which drug is used for radical cure of P. vivax malaria to eliminate hypnozoites?
Primaquine (after testing for G6PD deficiency).
What is the drug of choice (DOC) for lymphatic filariasis?
Diethylcarbamazine (DEC), often combined with albendazole.
Name the most common causative organism of community-acquired pneumonia.
Streptococcus pneumoniae.
What is the first-line drug for uncomplicated urinary tract infection (cystitis)?
Nitrofurantoin or trimethoprim-sulfamethoxazole (cotrimoxazole); fosfomycin is also used.
What is the empirical drug therapy for bacterial meningitis in adults?
A third-generation cephalosporin (ceftriaxone or cefotaxime) plus vancomycin; add ampicillin if Listeria is suspected.
Define peptic ulcer disease and name the main causative organism.
Erosion of the gastric/duodenal mucosa due to imbalance between aggressive (acid, pepsin) and protective factors; commonly caused by Helicobacter pylori and NSAIDs.
What is the standard 'triple therapy' for H. pylori eradication?
A proton pump inhibitor + clarithromycin + amoxicillin (or metronidazole) for 10-14 days.
Which drug class is first-line for chronic management of GERD?
Proton pump inhibitors (e.g., omeprazole, pantoprazole).
Why must drug dosing be adjusted in hepatic impairment?
Reduced hepatic metabolism, decreased first-pass effect, reduced plasma protein synthesis (more free drug), and portal-systemic shunting increase drug levels and toxicity risk.
How is drug dosing adjusted in renal impairment?
For renally cleared drugs, reduce the dose and/or extend the dosing interval based on creatinine clearance (Cockcroft-Gault) to avoid accumulation and toxicity.
State the Cockcroft-Gault equation for creatinine clearance.
CrCl (mL/min) = [(140 − age) × weight(kg) × 0.85 if female] ÷ (72 × serum creatinine in mg/dL).
List the first-line drug classes for chronic heart failure with reduced ejection fraction.
ACE inhibitors (or ARBs/ARNI), beta-blockers, mineralocorticoid receptor antagonists, and SGLT2 inhibitors; diuretics for symptom relief.
Which drug classes are used in the long-term management of asthma (controllers)?
Inhaled corticosteroids (mainstay), long-acting beta-2 agonists (LABA), leukotriene receptor antagonists, and LAMAs; SABAs for acute relief.
What is the diagnostic fasting plasma glucose threshold for diabetes mellitus?
Fasting plasma glucose ≥126 mg/dL, or HbA1c ≥6.5%, or 2-hour post-load glucose ≥200 mg/dL, or random glucose ≥200 mg/dL with symptoms.
Which oral antidiabetic drug is first-line for type 2 diabetes and why?
Metformin - it reduces hepatic glucose production, improves insulin sensitivity, is weight-neutral, carries low hypoglycaemia risk, and is cost-effective.
What is the drug of choice for hypothyroidism?
Levothyroxine (synthetic T4), taken on an empty stomach.
Name the two antithyroid drugs used for hyperthyroidism and a key risk.
Carbimazole/methimazole and propylthiouracil; both carry a risk of agranulocytosis.
What is the drug of choice for acute gout flare versus chronic gout prophylaxis?
Acute: NSAIDs, colchicine, or corticosteroids; Chronic prophylaxis: allopurinol or febuxostat (xanthine oxidase inhibitors).
What are the four phases of clinical trials?
Phase I: safety/dosing in healthy volunteers; Phase II: efficacy and side effects in patients; Phase III: large-scale confirmation vs standard treatment; Phase IV: post-marketing surveillance.
What is a placebo and what is the purpose of a double-blind design in clinical trials?
A placebo is an inert substance with no therapeutic activity used as a control; double-blinding (neither patient nor investigator knows the allocation) minimizes bias in assessing the true treatment effect.
What this deck covers
The Clinical Pharmacy and Therapeutics deck follows the GPAT Clinical Pharmacy and Therapeutics syllabus — 10 chapters and 31 topics — so questions land on material that is genuinely examinable rather than trivia around it. That works out to roughly 5.1 cards per chapter.
Answers are written to be recallable, not just readable — averaging about 109 characters, which is long enough to carry the reasoning and short enough to say out loud.
A deck like this earns its keep on the second and third pass. Read the syllabus first so you know the shape of the subject, then use the cards to find the specific facts that have not stuck.
Clinical Pharmacy and Therapeutics flashcards FAQ
How many Clinical Pharmacy and Therapeutics flashcards are in this GPAT deck?
51 cards. This page previews 24 of them, sampled evenly across the deck so you can judge the difficulty before installing anything.
Are these GPAT flashcards free?
Yes. The preview here is free to read with no signup, and the full 51-card deck is free inside the Examius app.
What do the Clinical Pharmacy and Therapeutics cards cover?
They follow the GPAT Clinical Pharmacy and Therapeutics syllabus — 10 chapters and 31 topics — so the questions track what is actually examinable.
How should I use these flashcards?
Read the syllabus first so you know the shape of the subject, then drill the deck. Examius schedules each card with spaced repetition, so cards you keep missing come back sooner and ones you know drift further apart.