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High School Equivalency Test (HiSET) Science Syllabus
The Science syllabus for High School Equivalency Test (HiSET) in full: 4 chapters, 17 topics and 35 sub-topics, every one listed below, plus 63 Science flashcards with answers.
Science syllabus: all 4 chapters
Expand any chapter to see its topics and sub-topics.
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Scientific Inquiry and Reasoning
4 topics- The Scientific Method
- Forming hypotheses and predictions
- Independent, dependent, and control variables
- Designing and Evaluating Experiments
- Controls and sources of error
- Reliability and validity
- Interpreting Scientific Data
- Reading graphs, tables, and diagrams
- Identifying trends and relationships
- Drawing Evidence-Based Conclusions
- Distinguishing observation from inference
- Evaluating competing explanations
- The Scientific Method
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Life Science
5 topics- Cells and Cellular Processes
- Cell structure and organelles
- Photosynthesis and cellular respiration
- Cell division
- Genetics and Heredity
- DNA, genes, and chromosomes
- Dominant and recessive traits, Punnett squares
- Human Body Systems
- Digestive, circulatory, and respiratory systems
- Nervous and immune systems
- Evolution and Natural Selection
- Adaptation and survival
- Evidence for evolution
- Ecology and Ecosystems
- Food chains, food webs, and energy flow
- Population dynamics and interdependence
- Cells and Cellular Processes
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Physical Science
4 topics- Structure and Properties of Matter
- Atoms, elements, and the periodic table
- States and changes of matter
- Chemical Reactions
- Reactants, products, and conservation of mass
- Acids, bases, and pH
- Forces and Motion
- Newton's laws
- Speed, velocity, and acceleration
- Energy
- Kinetic and potential energy
- Heat, light, sound, and electricity
- Structure and Properties of Matter
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Earth and Space Science
4 topics- Earth Materials and Geologic Processes
- Rocks, minerals, and the rock cycle
- Plate tectonics, earthquakes, and volcanoes
- Earth's Cycles
- Water cycle
- Carbon and nitrogen cycles
- Weather, Climate, and the Atmosphere
- Weather systems and patterns
- Climate change and human impact
- Astronomy and the Solar System
- Earth, Moon, and Sun relationships
- Planets, stars, and the universe
- Earth Materials and Geologic Processes
High School Equivalency Test (HiSET) Science flashcards — 63 questions with answers
What are the typical ordered steps of the scientific method?
Make an observation, ask a question, form a hypothesis, make a prediction, test it with an experiment, analyze the data, and draw a conclusion (then communicate/repeat).
What is a scientific hypothesis?
A testable, falsifiable proposed explanation for an observation, often stated as an 'if...then...' prediction.
In an experiment, what is the difference between the independent and dependent variable?
The independent variable is the factor the experimenter deliberately changes; the dependent variable is what is measured in response to that change.
What is a controlled variable (constant) in an experiment?
A factor kept the same across all groups so it does not influence the results, isolating the effect of the independent variable.
Why does a well-designed experiment include a control group?
The control group does not receive the experimental treatment, providing a baseline for comparison to show the treatment caused any observed effect.
What is the purpose of a large sample size and replication in an experiment?
They reduce the effect of random variation and chance, making results more reliable and the conclusions more valid.
What is the difference between a scientific theory and a scientific law?
A law describes WHAT happens (often mathematically); a theory explains WHY it happens, supported by a large body of evidence.
On a line graph, what does the slope of a line represent?
The rate of change of the dependent (y) variable with respect to the independent (x) variable.
What does correlation between two variables NOT prove?
Correlation does not prove causation; two variables can be related without one causing the other (a third factor may be involved).
What distinguishes a valid evidence-based conclusion from an opinion or assumption?
A valid conclusion is supported directly by the data collected and stays within what the evidence actually shows, without going beyond it.
What is the basic structural and functional unit of all living things?
The cell.
What is the main difference between prokaryotic and eukaryotic cells?
Prokaryotic cells lack a membrane-bound nucleus and organelles; eukaryotic cells have a true nucleus and membrane-bound organelles.
What is the function of the mitochondria?
It is the site of cellular respiration, producing ATP (energy) for the cell; the 'powerhouse' of the cell.
Write the overall word equation for photosynthesis.
Carbon dioxide + water + light energy → glucose + oxygen.
Write the overall word equation for cellular respiration.
Glucose + oxygen → carbon dioxide + water + energy (ATP).
What is the function of the cell membrane?
It is a selectively permeable barrier that controls what enters and leaves the cell.
What is the difference between diffusion and osmosis?
Diffusion is the movement of any solute from high to low concentration; osmosis is specifically the diffusion of water across a semipermeable membrane.
What is the difference between mitosis and meiosis?
Mitosis produces two identical diploid body cells; meiosis produces four genetically varied haploid gametes (sex cells).
What molecule carries the genetic instructions in cells, and what are its base pairs?
DNA; adenine pairs with thymine (A-T) and cytosine pairs with guanine (C-G).
What is the difference between a genotype and a phenotype?
Genotype is the genetic makeup (alleles, e.g., Bb); phenotype is the observable physical trait (e.g., brown eyes).
Show the other 43 Science flashcards
What is the difference between a dominant and a recessive allele?
A dominant allele is expressed whenever present; a recessive allele is only expressed when two copies are present (homozygous recessive).
In a Punnett square cross of two heterozygous parents (Bb x Bb), what is the genotype and phenotype ratio?
Genotype ratio 1 BB : 2 Bb : 1 bb; phenotype ratio 3 dominant : 1 recessive.
What determines biological sex in humans by chromosomes?
XX produces a female and XY produces a male; the father's sperm carries the X or Y that determines sex.
What is a genetic mutation?
A change in the DNA sequence, which can be harmful, beneficial, or neutral and may be passed to offspring if it occurs in gametes.
What is the main function of the circulatory system?
To transport blood, carrying oxygen, nutrients, hormones, and wastes throughout the body.
What is the function of the respiratory system, and where does gas exchange occur?
It brings oxygen into the body and removes carbon dioxide; gas exchange occurs in the alveoli of the lungs.
What is the function of the nervous system?
To detect stimuli and rapidly transmit electrical signals (via neurons) to coordinate body responses and process information.
What is homeostasis?
The maintenance of a stable internal environment (e.g., temperature, pH, glucose) despite external changes.
What is the role of the digestive system?
To break down food into nutrients the body can absorb and to eliminate solid waste.
What is natural selection?
The process by which organisms with traits better suited to their environment survive and reproduce more, passing those traits on (survival of the fittest).
What is biological evolution?
The change in the heritable characteristics (allele frequencies) of a population over successive generations.
Name three types of evidence that support evolution.
Fossil record, comparative anatomy (homologous structures), and molecular/DNA similarities (also embryology).
What is an adaptation?
An inherited trait that increases an organism's chance of survival and reproduction in its environment.
What is the source of new genetic variation that natural selection acts upon?
Mutation (and, in sexually reproducing organisms, genetic recombination).
In an ecosystem, what is the difference between a producer and a consumer?
Producers (autotrophs) make their own food via photosynthesis; consumers (heterotrophs) obtain energy by eating other organisms.
What is the role of decomposers in an ecosystem?
They break down dead organisms and waste, recycling nutrients back into the environment.
Roughly what percentage of energy is passed to the next trophic level in a food chain?
About 10%; the other ~90% is lost mainly as heat through life processes.
What is the difference between a food chain and a food web?
A food chain shows a single linear path of energy flow; a food web shows many interconnected food chains in an ecosystem.
What is the difference between an element, a compound, and a mixture?
An element is one type of atom; a compound is two or more elements chemically bonded; a mixture is substances physically combined and not chemically bonded.
What are the three subatomic particles and their charges?
Protons (positive) and neutrons (neutral) in the nucleus, and electrons (negative) orbiting it.
What does the atomic number of an element tell you?
The number of protons in the atom's nucleus, which identifies the element.
What distinguishes a physical change from a chemical change?
A physical change alters form but not identity (e.g., melting); a chemical change forms new substances (e.g., burning).
What is the law of conservation of mass?
In a chemical reaction, matter is neither created nor destroyed; the total mass of reactants equals the total mass of products.
In a chemical equation, what are reactants and products?
Reactants are the starting substances (left of the arrow); products are the substances formed (right of the arrow).
On the pH scale, what values indicate acids, bases, and neutral?
Below 7 is acidic, exactly 7 is neutral, and above 7 is basic (alkaline).
What is Newton's first law of motion (the law of inertia)?
An object at rest stays at rest and an object in motion stays in motion at constant velocity unless acted on by an unbalanced (net) force.
State Newton's second law of motion as a formula.
Force = mass × acceleration (F = ma).
What is the formula for speed?
Speed = distance ÷ time.
What is the difference between kinetic and potential energy?
Kinetic energy is the energy of motion; potential energy is stored energy due to position or condition (e.g., gravitational PE).
What is the law of conservation of energy?
Energy cannot be created or destroyed, only transformed from one form to another; total energy stays constant.
What are the three main types of rocks and how does each form?
Igneous (cooled magma/lava), sedimentary (compacted/cemented sediments), and metamorphic (existing rock changed by heat and pressure).
What are the three layers of Earth's interior from outside to center?
Crust, mantle, and core (the core has a liquid outer core and solid inner core).
What is the theory of plate tectonics?
Earth's lithosphere is broken into plates that move on the mantle, causing earthquakes, volcanoes, and mountain building at their boundaries.
What are the main steps of the water cycle?
Evaporation, condensation, precipitation, and collection/runoff (with transpiration from plants).
What is weathering versus erosion?
Weathering is the breaking down of rock in place; erosion is the transport of those weathered materials by wind, water, or ice.
What is the difference between weather and climate?
Weather is the day-to-day state of the atmosphere; climate is the average weather pattern of a region over many years.
What gas in the atmosphere is most responsible for protecting Earth from harmful UV radiation?
Ozone (O3), found in the stratosphere's ozone layer.
What causes the greenhouse effect?
Greenhouse gases (like CO2, water vapor, and methane) trap heat radiated from Earth's surface, warming the atmosphere.
What causes Earth's seasons?
The tilt of Earth's axis (about 23.5°) as it orbits the Sun, changing the angle and duration of sunlight received by each hemisphere.
What causes the phases of the Moon?
The changing relative positions of the Moon, Earth, and Sun, which change how much of the Moon's sunlit side we see from Earth.
What is the difference between rotation and revolution for Earth?
Rotation is Earth spinning on its axis (one day); revolution is Earth orbiting the Sun (one year).
List the planets of the solar system in order from the Sun.
Mercury, Venus, Earth, Mars, Jupiter, Saturn, Uranus, and Neptune.
What force keeps the planets in orbit around the Sun?
Gravity, the attractive force between masses.
High School Equivalency Test (HiSET) Science FAQ
What is in the High School Equivalency Test (HiSET) Science syllabus?
High School Equivalency Test (HiSET) Science is split into 4 chapters: Scientific Inquiry and Reasoning, Life Science, Physical Science and Earth and Space Science. Together they contain 17 topics and 35 sub-topics.
How many chapters are in High School Equivalency Test (HiSET) Science?
4 chapters, containing 17 topics and 35 sub-topics. The largest chapter is Life Science, with 5 topics.
Are there flashcards for High School Equivalency Test (HiSET) Science?
Yes — a 63-card Science deck, printed in full in the flashcards section of this page and available in the Examius app with spaced repetition. The free plan covers one exam of your choice, including its flashcards; Examius Pro, a one-time purchase, unlocks every other exam and deck.